| The association between smoking and clinical manifestations in patients with Behçet’s disease |
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Shin-Seok Lee, Chan-Bum Choi, Eun-Kyoung Lee, Sung-Hoon Park, Jung-Yoon Choe, Seong-Kyu Kim |
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Cardiology Division, Department of Internal Medicine, Yeungnam University Hospital1 |
| 원저 : 흡연과 베체트병의 임상증상 발현과의 관련성 고찰 |
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이신석.최찬범.이은경.박성훈.최정윤.김성규, Chan-Bum Choi, Eun-Kyoung Lee, Sung-Hoon Park, Jung-Yoon Choe, Seong-Kyu Kim |
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| Abstract |
Background/Aims
There is controversy related to the role of smoking in affecting the clinical features of patients with Behçet’s disease (BD). The aim of this study was to investigate the effect of smoking on clinical manifestations in Korean BD patients.
Methods
We enrolled 131 patients with BD who fulfilled the International Study Group (ISG) criteria of 1990. The disease-related clinical features of BD―oral ulcers, genital ulcers, ocular lesions, arthritis, vascular lesions, gastrointestinal lesions―and central nerve lesions, smoking history, disease duration, and the presence of HLA-B51 were retrospectively assessed through medical record reviews and patient interviews. Statistical analysis was performed using Chi-square, Fisher’s exact, or student t-test, if appropriate.
Results
The frequencies of vascular and gastrointestinal lesions in smokers were significantly increased compared to those in non-smokers (p=0.040, OR=3.341, 95% CI 1.083-10.305; p=0.012, OR=3.878, 95% CI 1.379-10.906, respectively). Male smokers developed vascular lesions more frequently compared to female smokers, male non-smokers, and female non-smokers (p=0.025, OR=3.896, 95% CI 1.245-12.196). Moreover, smoking, male sex, and positive HLA-B51 may be risk factors for the development of gastrointestinal lesions in BD. Venous lesions were more frequently found in male smokers compared with other patients (p=0.038).
Conclusions
Smoking may be associated with the development of vascular and gastrointestinal lesions in Korean BD patients. A large population prospective assessment of the clinical effect of smoking on BD is needed. (Korean J Med 75:202-209, 2008)
Key Words: Behçet’s disease; Smoking; Male; HLA-B51 |
| Key Words:
Behçet’s disease; Smoking; Male; HLA-B51 |
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