| A case of severe aplastic anemia induced by d-penicillamine in systemic scleroderma |
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Dong Won Lee, Sun Mi Lee, Jun Hee Lee, Ho-Jin Sin, Joo-Seop Chung, Goon-Jae Cho, Sung Il Kim |
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Department of Medicine, Sungkyunkwan University School of Medicine |
| 증례 : 전신성 경화증에서 D-penicillamine 치료 중에 발생한 중증 재생불량성 빈혈 1예 |
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이동원&#;이선미&#;이준희&#;신호진&#;정주섭&#;조군제&#;김성일, Sun Mi Lee, Jun Hee Lee, Ho-Jin Sin, Joo-Seop Chung, Goon-Jae Cho, Sung Il Kim |
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| Abstract |
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D-penicillamine has been used in treating systemic scleroderma (SSc) to reduce skin thickening and to prevent further involvement of internal organs. Well known side effects include skin rash, changes or loss of taste, nausea and vomiting, hematologic complications such as thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia and autoimmune disease such as Goodpasture's syndrome, myasthenia gravis, polymyositis, and systemic lupus erythematosis. Aplastic anemia is a rare complication and is usually resolved by discontinuing medication.
We experienced a case of D-penicillamine-induced severe aplastic anemia in systemic scleroderma patient and would like to report this case with review of articles.(Korean J Med 69:S970-S973, 2005) |
| Key Words:
D-penicillamine, Aplastic anemia, Systemic Scleroderma |
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