| A case of rapidly progressive renal failure induced by cadmium intoxication |
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Eun Young Lee, Ho Sik Shin, Yeon Soon Jung, Bong Kwon Chun, Hark Rim |
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조선대학교 의과대학 내과학교실 |
| 급성 카드뮴 중독에 의한 급속 진행성 신부전 1예 |
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이은영, 신호식, 정연순, 천봉권, 임 학 |
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Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea |
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| Abstract |
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Cadmium (Cd)-induced renal damage primarily affects the cellular and functional integrity of the proximal tubules. Cd intoxication
is a rare cause of Fanconi syndrome. We report a 31-year-old woman with Fanconi syndrome confirmed by laboratory
findings and a renal biopsy that also showed an elevated urinary Cd. Seven months before admission, the patient had a normal urinalysis
and renal function. Six and 3 months before admission, the patient ingested Chinese herbal mixtures. On admission, the
blood Cd concentration was normal, and the urine Cd concentration was 58 μg/g of creatinine, 29-times higher than the normal
range. A renal biopsy showed degeneration of the proximal tubules with normal glomeruli. The serum creatinine had increased
from 1.2 to 3.2 mg/dL over 8 months. This case of Fanconi syndrome and rapidly progressive renal damage over a short period was
associated with elevated urinary Cd levels. (Korean J Med 78:761-765, 2010) |
| Key Words:
Kidney failure; Fanconi syndrome; Cadmium |
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