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Korean J Med > Volume 88(4); 2015 > Article
The Korean Journal of Medicine 2015;88(4): 357-362.
급성 신손상의 정의와 평가: 임상 진료 지침
김동기, 주권욱
서울대학교 의과대학 내과학교실 신장내과
Definition and Evaluation of Acute Kidney Injury: Clinical Practice Guidelines
Dong Ki Kim, Kwon-Wook Joo
Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Corresponding Author: Kwon-Wook Joo ,Tel: +82-2-2072-2496, Fax: +82-2-745-2264, Email: junephro@snu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Acute kidney injury (AKI) is a common clinical syndrome that carries a poor prognosis even in cases with seemingly mild or reversible renal dysfunction. Although this potentially devastating disease is associated with increased mortality, early detection and timely intervention may improve clinical outcomes. In this regard, a standardized definition and classification of AKI, reflecting prognosis on the basis of evidence, may allow early recognition and stage-based management of the disease. Nevertheless, there has been considerable variability and inconsistency in the definition and classification of AKI, resulting in failure to bridge the gap between research and clinical practice. The definition of AKI has evolved, with the introduction of the “Risk, Injury, Failure, Loss, and End-stage renal disease” (RIFLE), and “AKI Network” (AKIN) criteria. The recent “Kidney Disease Improving Global Outcomes” (KDIGO) guidelines proposed a uniform definition of AKI, essentially merging the RIFLE and AKIN criteria. This review will focus on the definition and classification of AKI, as proposed by KDIGO in 2012, and their use in clinical practice for clinicians.
Keywords: Acute kidney injury; Clinical practice guideline; Kidney disease improving global outcomes (KDIGO)
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