| A Case of Primary Mediastinal Choriocarcinoma Mimicking Large Cell Carcinoma of the Lung in a Male Patient in His 50s |
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Young Shin Kim, Chi Wha Han, Yun Hwa Jung, Min Young Jeong, Seong Woo Go, Kyung Jin Yun, Han Hee Chung |
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Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea |
| 50대 남자 환자에서 대세포 폐암으로 오인된 원발성 종격동 융모막암 1예 |
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김영신, 한치화, 정윤화, 정민영, 고성우, 윤경진, 정한희 |
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가톨릭대학교 의과대학 내과학교실 |
Correspondence:
Chi Wha Han, Tel: +82-2-3779-2428, Fax: +82-2-780-3132, Email: cwhan@unitel.co.kr
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Received: 23 July 2013 • Revised: 17 September 2013 • Accepted: 11 October 2013 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Primary mediastinal choriocarcinoma is an extremely rare extragonadal germ cell malignancy. A 58-year-old male presented with a lung mass, which was incidentally discovered during a periodic medical checkup. Percutaneous needle biopsy showed poorly differentiated carcinoma with large pleomorphic morphology. After the patient underwent right upper lobectomy and lymphadenectomy, the final diagnosis was choriocarcinoma. The patient received four sequential cycles of BEP chemotherapy (bleomycin, etoposide, cisplatin). After completion of BEP chemotherapy, follow-up positron emission tomography (PET) showed a complete metabolic response. Although the mediastinum is one of the most common primary sites of extragonadal germ cell tumors, primary mediastinal choriocarcinoma is liable to be misdiagnosed as lung cancer or Hodgkin lymphoma. Notably, large cell carcinoma of the lung can be confused with choriocarcinoma even after percutaneous needle biopsy. We report a case of primary mediastinal choriocarcinoma mimicking large cell carcinoma of the lung in a male patient in his 50s. (Korean J Med 2014;86:641-646) |
| Key Words:
Primary mediastinal choriocarcinoma; Large cell carcinoma |
| 주제어:
원발성 종격동 융모막암종; 대세포 폐암 |
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