| A Case of Hepatocellular Carcinoma in a Patient with Crohn’s Disease |
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Seung Hyeon Jang, Jee Hyun Kim, Jae Woo Lee, June Young Lee, Young Youn Cho, Won-Mook Choi, Hyun Chae Jung |
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Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea |
| 크론병 환자에서 발생한 간세포암 1예 |
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장승현, 김지현, 이재우, 이준영, 조영윤, 최원묵, 정현채 |
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서울대학교 의과대학 내과학교실, 간연구소 |
Correspondence:
Hyun Chae Jung, Tel: +82-2-740-8112, Fax: +82-2-743-6701, Email: hyunchae@snu.ac.kr
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Received: 1 May 2014 • Revised: 1 September 2014 • Accepted: 25 October 2014 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Abstract |
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Hepatocellular carcinomas (HCCs) in patients with Crohn’s disease (CD) without underlying chronic hepatitis or liver cirrhosis are extremely rare. Previously reported cases occurred in patients who had developed CD at a young age and had been treated with immunosuppressive agents long-term. We herein report the first case of HCC in a 34-year-old patient with CD in Korea. The patient was treated with azathioprine for 14 years and had undergone repeated surgeries for CD. During the follow-up period, the patient was hospitalized for colon perforation and pericolic abscess formation. Computed tomography showed a liver mass, and HCC was diagnosed based on liver biopsy. The patient underwent right hemicolectomy for colon perforation and transcatheter arterial chemoembolization followed by radiofrequency ablation for the HCC. The present case is similar to previously reported cases with the exception of the liver pathology findings, which exhibited neither primary sclerosing cholangitis nor focal hepatic glycogenolysis. |
| Key Words:
Hepatocellular carcinoma; Crohn disease; Azathioprine; Infliximab |
| 주제어:
간세포암; 크론병; 아자티오프린; 인플릭시맙 |
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