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The Korean Journal of Medicine 2010;78(2): 191-197.
전당뇨병 환자에서 ApoB/ApoA-I Ratio와 비알코올성 지방간과의 연관성
이지애, 장승훈, 민재훈, 김태완, 정우신, 심충남, 허운제, 정미연, 이현아, 조용균, 홍현표
The relationship between the ApoB/ApoA-I ratio and non-alcoholic fatty liver disease in prediabetic patients
Ji Ae Lee, Seung Hun Jang, Jae Hoon Min, Tae Wan Kim, Woo Shin Jeong, Choong Nam Shim, Woon Je Heo, Mi Youn Jung, Hyon A Lee, Yong Kyun Cho, Hyun Pyo Hong
ABSTRACT
Background/Aims:
The apolipoprotein B/A-I ratio (ApoB/A-I) is a powerful clinical indicator of atherosclerosis. Although numerous reports have shown the effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular disease, few reports have examined the relationship between NAFLD and the ApoB/A-I ratio. The aim of the study was to determine the association between NAFLD and the ApoB/A-I ratio in prediabetic patients.
Methods:
This cross-sectional study was performed with data obtained from 701 patients (mean age, 47.9±9.6 years) diagnosed with prediabetes. Serum lipid profiles including lipoprotein, apolipoprotein, and calculated ApoB/A-I ratio as well as metabolic syndrome parameters such as fasting glucose and insulin were measured in each subject.
Results:
Among the 701 patients, 340 (48%) had NAFLD. The number of male patients was 490 (NAFLD+, 276; and NAFLD-,214). The odds ratios for the prevalence of NAFLD increased according to the quartiles of the ApoB/A-I ratio (1.886, 2.245, and 2.587) (p<0.001).
Conclusions:
The prevalence of NAFLD correlated with high ApoB/A-I ratio, suggesting that NAFLD increases the risk for atherosclerosis progression in male prediabetic patients. (Korean J Med 78:191-197, 2010)
Keywords: NAFLD; Apolipoprotein B; Apolipoprotein A-I; Prediabetes; Atherosclerosis
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