| The relationship between the ApoB/ApoA-I ratio and non-alcoholic fatty liver disease in prediabetic patients |
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Ji Ae Lee, Seung Hun Jang, Jae Hoon Min, Tae Wan Kim, Woo Shin Jeong, Choong Nam Shim, Woon Je Heo, Mi Youn Jung, Hyon A Lee, Yong Kyun Cho, Hyun Pyo Hong |
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| 전당뇨병 환자에서 ApoB/ApoA-I Ratio와 비알코올성 지방간과의 연관성 |
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이지애, 장승훈, 민재훈, 김태완, 정우신, 심충남, 허운제, 정미연, 이현아, 조용균, 홍현표 |
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| Abstract |
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Background/Aims: The apolipoprotein B/A-I ratio (ApoB/A-I) is a powerful clinical indicator of atherosclerosis. Although numerous reports have shown the effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular disease, few reports have examined the relationship between NAFLD and the ApoB/A-I ratio. The aim of the study was to determine the association between NAFLD and the ApoB/A-I ratio in prediabetic patients.
Methods: This cross-sectional study was performed with data obtained from 701 patients (mean age, 47.9±9.6 years) diagnosed with prediabetes. Serum lipid profiles including lipoprotein, apolipoprotein, and calculated ApoB/A-I ratio as well as metabolic syndrome parameters such as fasting glucose and insulin were measured in each subject.
Results: Among the 701 patients, 340 (48%) had NAFLD. The number of male patients was 490 (NAFLD+, 276; and NAFLD-,214). The odds ratios for the prevalence of NAFLD increased according to the quartiles of the ApoB/A-I ratio (1.886, 2.245, and 2.587) (p<0.001).
Conclusions: The prevalence of NAFLD correlated with high ApoB/A-I ratio, suggesting that NAFLD increases the risk for atherosclerosis progression in male prediabetic patients. (Korean J Med 78:191-197, 2010) |
| Key Words:
NAFLD; Apolipoprotein B; Apolipoprotein A-I; Prediabetes; Atherosclerosis |
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