Korean J Med > Volume 74(1); 2008 > Article
The Korean Journal of Medicine 2008;74(1):222-227.
A case of Hashimoto’s encephalopathy with focal cerebral perfusion defect
Yun Jeung Kim, Ihn Suk Lee, Ju Hee Lee, Youn Sun Bai, Young Suk Jo, Heung Kyu Ro, Minho Shong
성균관대학교 의과대학 삼성서울병원 심장혈관센터 순환기내과
증례 : 국소 뇌혈류 관류 감소를 동반한 하시모토 뇌병증 1예
김윤정, 이인석, 이주희, 배연선, 조영석, 노흥규, 송민호
Abstract
Hashimoto encephalopathy (HE) is a rare clinical condition associated with Hashimoto thyroiditis. Patients with HE usually have three specific characteristics: (1) elevated thyroid autoantibody titer, (2) neuropsychiatric symptoms such as seizure, altered consciousness, cognitive dysfunction, or speech and behavior impairment, and (3) good response to steroid therapy. Although the etiology and causative mechanism of HE are still unknown and precise methods for diagnosing HE have not been established, current diagnostic strategy depends on the findings that (1) the protein content of the cerebrospinal fluid is elevated, (2) brain waves become slower on electroencephalogram, (3) subcortical signal intensity increases on brain magnetic resonance imaging, and (4) cerebral perfusion verified by using single photon emission computed tomography (SPECT) decreases through the entire brain. We report a case of typical HE, showing a focal decrease in cerebral perfusion as verified by SPECT, along with a literature review.
Key Words: Encephalopathy; Hashimoto thyroiditis; SPECT


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