| A case of warfarin-induced hepatitis |
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Ji Young Park, Byoung Hoon Lee, Oh-Sung Kwon, Chaeyoung Lim, Se Young Kim, Si Min Kim, Sang Hoon Kim |
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경희대학교 의과대학 순환기내과학교실 |
| 증례 : 와파린에 의한 약인성 간염 1예 |
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박지영, 이병훈, 권오성, 임채영, 김세영, 김시민, 김상훈 |
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| Abstract |
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Warfarin-induced liver disease is an uncommon entity which can cause acute hepatitis. A 66-year-old man was admitted to the hospital presenting with dyspnea and hypoxemia. Contrast-enhanced computed tomography of the chest showed massive intraluminal filling defects in both pulmonary arteries. We diagnosed this patient with pulmonary artery thromboembolism and treated him with low molecular weight heparin and warfarin. After 3 days, we stopped low molecular weight heparin and continued therapy with warfarin. After 8 days, the patient complained of nausea, and AST, ALT, and total bilirubin were found to be elevated. We did not use hepatotoxic drugs, except warfarin. Viral and autoimmune hepatitis markers were all negative. We did not find any lesions on contrast-enhanced computed tomography of the abdomen. After stopping warfarin, AST, ALT, and total bilirubin decreased. We diagnosed the patient with warfarin-induced hepatitis. Thus, we report this rare case together with a review of the literature. |
| Key Words:
Warfarin; Hepatitis; Adverse drug reaction |
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