| A case of ifosfamide-induced renal tubular acidosis and renal failure |
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Jin Woo Lee, Hyun Chul Chung, Hyo Sup Lee, Su Jin Sin, Hyun Soo Kim, Jong Soo Lee, Hee Jeong Cha |
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Department of Medicine, Sungkyunkwan University School of Medicine |
| 증례 : 성인에서 ifosfamide 치료에 의해 발생한 신세뇨관 산증과 신부전 1예 |
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이진우&#;정현철&#;이효섭&#;신수진&#;김현수&#;이종수&#;차희정, Hyun Chul Chung, Hyo Sup Lee, Su Jin Sin, Hyun Soo Kim, Jong Soo Lee, Hee Jeong Cha |
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| Abstract |
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Ifosfamide is an alkylating agent with remarkable activity against a wide range of tumors. The adverse effect most frequently reported is hemorrhagic cystitis. However, the increasing use of ifosfamide has revealed that nephrotoxicity is a potentially serious complication which may include renal tubular acidosis and rarely chronic renal impairment. A 58-year-old woman, Hodgkin lymphoma with bone and lung metastases was diagnosed in April, 2002. At the time of diagnosis, the serum creatinine was 0.96 mg/dL with no abnormal findings in urinalysis. After five cycles of chemotherapy consisting of ifosfamide, navelbine, and prednisone, patient's urinalysis showed proteinuria, glycosuria, ketonuria, and microscopic hematuria. On October, 2002, the patient received the sixth treatment cycle. Three months later, she presented with general weakness, nocturia, and urinary frequencies. She developed severe renal tubular acidosis and her serum creatinine was 3.7 mg/dL. The serum creatinine level increased progressively over the next 7 months and hemodialysis was needed.(Korean J Med 69:S890-S895, 2005) |
| Key Words:
Ifosfamide, Renal tubular acidosis, Chronic renal failure |
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