| A case of Wilson’s disease complicated by hepatocellular carcinoma |
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Hwi Young Kim, Joo Kyung Park, Joo Hyun Shim, Jeong Hoon Lee, Yoon Jun Kim, Jung-Hwan Yoon, Hyo-Suk Lee |
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Department of Medicine, Sungkyunkwan University School of Medicine |
| 증례 : 간세포암이 병발한 윌슨병(Wilson’s disease) 1예 |
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김휘영&#;박주경&#;심주현&#;이정훈&#;김윤준&#;윤정환&#;이효석, Joo Kyung Park, Joo Hyun Shim, Jeong Hoon Lee, Yoon Jun Kim, Jung-Hwan Yoon, Hyo-Suk Lee |
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| Abstract |
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In Wilson's disease, liver cirrhosis is a common complication. However, hepatocellular carcinoma rarely develops in Wilson's disease, in contrast to other liver diseases, such as postnecrotic cirrhosis or hemochromatosis. It has been speculated that the accumulated copper in the liver may prevent the development of hepatocellular carcinoma and the use of chelating agents may decrease the copper in the liver resulting in the development of carcinoma. However, there are various evidences contradicting this hypothesis. We report a 45-year-old male patient of Wilson's disease with hepatocellular carcinoma, and the literature was reviewed.(Korean J Med 69:S782-S786, 2005) |
| Key Words:
Wilson's disease, Hepatocellular carcinoma, Copper, Penicillamine, Zinc |
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