Clinical Impact of High Triglycerides and Central Obesity in Patients with Acute
Myocardial Infarction who Underwent Percutaneous Coronary Intervention

Han, Soo Gyoung; Jeong, Myung Ho; Rhee, Jung Ae; Choi, Jin Su; Lee, Kee Hong; Park, Keun Ho; Sim, Doo Sun; Hong, Young Joon; Kim, Ju Han; Ahn, Young Keun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee

doi:2014.86.2.169

Korean J Med > Volume 86(2); 2014 > Article

Original Article

The Korean Journal of Medicine 2014;86(2):169-178.
Published online February 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.2.169

Clinical Impact of High Triglycerides and Central Obesity in Patients with Acute Myocardial Infarction who Underwent Percutaneous Coronary Intervention

Soo Gyoung Han^1,2, Myung Ho Jeong^1,2,4, Jung Ae Rhee³, Jin Su Choi³, Kee Hong Lee^1,2,4, Keun Ho Park^1,2,4, Doo Sun Sim^1,2,4, Young Joon Hong^1,2,4, Ju Han Kim^1,2,4, Young Keun Ahn^1,2,4, Jeong Gwan Cho^1,2,4, Jong Chun Park^1,2, Jung Chaee Kang^1,2

¹The Heart Center of Chonnam National University Hospital, Gwangju, Korea
²The Heart Research Center Designated by Korea Ministry of Health and Welfare, Gwangju, Korea
³Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea
⁴Korea Cardiovascular Stent Research Institute, Chonnam National University, Gwangju, Korea

고중성지방혈증과 복부비만이 관상동맥 중재술을 시술받은 급성 심근경색증 환자의 임상경과에 미치는 영향

한수경^1,2, 정명호^1,2,4, 이정애³, 최진수³, 이기홍^1,2,4, 박근호^1,2,4, 심두선^1,2,4, 홍영준^1,2,4, 김주한^1,2,4, 안영근^1,2,4, 조정관^1,2,4, 박종춘^1,2, 강정채^1,2

^¹전남대학교병원 심장센터
^²보건복지부 지정 심장질환 특성화 연구센터
^³전남대학교 의과대학 예방의학교실
^⁴한국심혈관스텐트연구소

Correspondence:
Myung Ho Jeong, Tel: +82-62-220-6243, Fax: +82-62-228-7174, Email: myungho@chollian.net

Received: 3 November 2012 • Revised: 26 November 2012 • Accepted: 13 February 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims
Dyslipidemia and obesity are risk factors for the development of acute myocardial infarction (AMI) that affect the clinical outcomes in patients.
Methods
We analyzed 2,751 consecutive AMI patients who underwent percutaneous coronary intervention (PCI) (mean age, 63.7 ± 12.1 years). The patients were divided into four groups based on serum triglyceride levels and central obesity [Group Ia: triglycerides < 200 mg/dL and (-) central obesity; Group Ib: triglyceride < 200 mg/dL and (+) central obesity; Group IIa: triglyceride ≥ 200 mg/dL and (-) central obesity; Group IIb: triglyceride ≥ 200 mg/dL and (+) central obesity]. In-hospital outcome was defined as in-hospital mortality and complications. One-year clinical outcome was compared and defined as the composite of 1-year major adverse cardiac events (MACE), including death, recurrent MI, and target vessel revascularization.
Results
Total MACE developed in 502 patients (18.2%), while 303 patients (11.0%) died prior to the 1-year follow-up visit. In-hospital complications and in-hospital mortality were not different among the four groups. One-year clinical outcomes based on triglyceride levels (Group I vs. Group II) were not different. In addition, there were no differences in clinical outcomes in patients with a triglyceride level < 200 mg/dL, regardless of central obesity. One-year MACE rates were not significantly different among the four groups.
Conclusions
There was no significant difference in the 1-year MACE rate based on the triglyceride level and presence of central obesity in patients with AMI who underwent PCI. (Korean J Med 2014;86:169-178)

Key Words: Acute myocardial infarction; Obesity; Triglyceride; Mortality

주제어: 급성 심근경색증; 중성지방; 복부비만; 사망률