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Korean J Med > Volume 88(6); 2015 > Article
소화기
The Korean Journal of Medicine 2015;88(6): 635-642.
경구 C형 간염 치료제를 이용한 만성 C형 간염의 치료
이혜원1, 정규식1, 안상훈1,2,3
1연세대학교 의과대학 내과학교실
2연세대학교 의과대학 소화기병연구소
3두뇌한국21 플러스 사업
Treatment of Chronic Hepatitis C Using Newly Developed Oral Antiviral Agents
Hye Won Lee1, Kyu Sik Jung1, Sang Hoon Ahn1,2,3
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
2Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
3Brain Korea 21 Project of Medical Science, Seoul, Korea
Corresponding Author: Sang Hoon Ahn ,Tel: +82-2-393-6884, Fax: +82-2-2228-1936, Email: ahnsh@yuhs.ac
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Standard care for chronic hepatitis C has been a combination of pegylated interferon-alpha and ribavirin, although this treatment has suboptimal antiviral efficacy and significant adverse events. The hepatitis C virus treatment landscape has been transformed recently by the development of direct-acting antiviral agents (DAAs) that target NS3 protease, NS5A protein, and NS5B polymerase. Several DAAs showed potent antiviral activity leading to increased rates of sustained virological response (SVR), even in difficult-to-treat patients such as older patients and those with advanced liver disease and prior failed peg-interferon/ribavirin treatment. Use of multiple DAAs without pegylated interferon has shown dramatically high SVR rates (up to nearly 100%) with negligible side effects. Interferon-free regimens are close to becoming the new standard of care for patients with chronic hepatitis C in USA and Europe. Similarly, several DAAs are near clinical use in Korea. This review discusses DAAs that have been approved or are under investigation for approval in Korea.
Keywords: Chronic hepatitis C; Direct acting antivirals; Peginterferon
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