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Korean J Med > Volume 88(6); 2015 > Article
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The Korean Journal of Medicine 2015;88(6): 643-646.
특수한 경우의 C형 간염 치료: 간경변증
곽금연
성균관대학교 의과대학 삼성서울병원 내과
Treatment of Hepatitis C in Special Conditions: Liver Cirrhosis
Geum-Youn Gwak
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Geum-Youn Gwak ,Tel: +82-2-3410-3409, Fax: +82-2-3410-6983, Email: gy.gwak@samsung.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Acquiring a sustained virological response (SVR) in patients with cirrhosis or advanced hepatic fibrosis reduces liver disease-related mortality and the incidence of hepatocellular carcinoma. However, the SVR rate of the current standard of care, which is combination therapy with peg-interferon-alpha and ribavirin, is significantly lower, and treatment-related complications occur more frequently in patients with cirrhosis. Thus, antiviral treatment should be individualized in this population. This review high-lights the issues associated with anti-hepatitis C virus treatment in patients with compensated and decompensated cirrhosis.
Keywords: Hepatitis C; Cirrhosis; SVR; Antiviral therapy
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