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Korean J Med > Volume 88(2); 2015 > Article
The Korean Journal of Medicine 2015;88(2): 231-235.
식도암 환자에서 발생한 항이뇨 호르몬 부적절 분비 증후군 1예
이소연, 신성호, 이재혁, 안재성, 도병주, 장근두, 송헌호
한림대학교 의과대학 강동성심병원 내과
Case of Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Patient with Esophageal Cancer
SoYon Rhee, SungHo Shin, JaeHyuk Lee, JaeSung An, ByongJoo Do, Geundoo Jang, Hunho Song
Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
Corresponding Author: Hunho Song ,Tel: +82-2-2224-2691, Fax: +82-2-478-6925, Email: hunhos@hallym.or.kr
Received: February 22, 2014;   Revised: April 7, 2014;   Accepted: June 13, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) may be observed in various types of cancer, but is mainly seen in small-cell carcinoma. It can also be caused by several chemotherapeutic agents. However, it is a very rare phenomenon in esophageal cancer or its treatment. We report here on a case of SIADH related to esophageal cancer treatment. A 55-year-old man received chemoradiotherapy (CRT) for esophageal cancer. After receiving CRT for 5 days, he complained of nausea, dizziness, and general weakness, and his sodium level had dropped to 107 mEq/L. His volume status was clinically euvolemic and there were no edema or pigmentation. After hypertonic saline infusion, the sodium level increased and the symptoms improved. There have been several reports of SIADH associated with malignancies or chemotherapy agents. However, to the best of our knowledge, this is the first Korean case of SIADH associated with esophageal cancer that occurred after cisplatin treatment.
Keywords: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH); Esophageal cancer; Cisplatin; Chemoradiotherapy
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