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Korean J Med > Volume 87(3); 2014 > Article
The Korean Journal of Medicine 2014;87(3): 311-317.
비결핵항산균에 의한 피부, 연부조직 감염 9예
김효훈, 김신우, 장현하, 김혜인, 정주영, 진 선, 박정화, 정혜진, 김민혜, 이종명
경북대학교 의학전문대학원 내과학교실
Nine Cases of Soft Tissue Infection Due to Non-Tuberculous Mycobacterium
Hyo-Hoon Kim, Shin-Woo Kim, Hyun-Ha Chang, Hye-In Kim, Ju-Young Jeong, Sun Jin, Jung-Wha Park, Hye-Jin Jung, Min-Hye Kim, Jong-Myung Lee
Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea
Corresponding Author: Shin-Woo Kim ,Tel: +82-53-420-6525, Fax: +82-53-424-5542, Email: ksw2kms@knu.ac.kr
Received: September 8, 2013;   Revised: November 18, 2013;   Accepted: February 27, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Non-tuberculous Mycobacterium (NTM) infections usually result in chronic disease, and making a diagnosis is often difficult. Skin and soft tissue infections due to NTM are not common and are usually diagnosed relatively late. We investigated the clinical characteristics of nine cases of skin and soft tissue infections with NTM.
Nine patients with an NTM infection who were confirmed consecutively by skin and soft tissue and/or adjacent bone cultures at a teaching hospital between August 2006 and July 2013 were enrolled in this study. The demographics, clinical characteristics, underlying diseases, treatment, and prognosis between different NTM species were reviewed retrospectively.
The most common NTM species causing a soft tissue infection was Mycobacterium abscessus (five patients, 55.6%). Common sites of infection were the knee and lumbar spine. Five patients (55.6%) had underlying diseases. Six patients (77.8%) were treated with combined surgical treatment (incision and drainage) plus antibiotics. The duration from symptom onset to diagnosis was long (77.7 ± 44.6 days) due to inadequate microbiological evaluation and disregard for the clinical significance of the NTM culture. All patients were cured with treatment; however, the treatment duration was long (181.7 ± 140.0 days). Procedure and cosmetic surgery were the most important risk factors for infection.
The diagnosis of NTM skin and soft tissue infections tends to be delayed in a clinical setting. Therefore, a high index of suspicion for NTM infection in chronic localized soft tissue infections is essential for diagnosis. Mycobacterium abscessus appears to be the most common NTM species causing soft tissue infections.
Keywords: Mycobacterium infections; Non-tuberculous; Skin diseases; Soft tissue infections
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