Korean J Med > Volume 77(5); 2009 > Article
The Korean Journal of Medicine 2009;77(5):1342-1346.
A case of Etanercept-associated malignant lymphoma in a patient with rheumatoid arthritis
Sang Kyung Jung, Ju Hyun Lee, June Sung Lee, Hye Ran Lee, Sun Hee Chang, Bo Young Yoon
Etanercept으로 치료한 류마티스관절염 환자에서 발생한 악성 림프종 1예
정상경·이주현·이준성·이혜란·장선희·윤보영, Ju Hyun Lee, June Sung Lee, Hye Ran Lee, Sun Hee Chang, Bo Young Yoon
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis that is associated with an increased risk of coronary artery disease, infection, lymphoma, and life expectancy. Several studies have shown that patients with RA have a 2~3x increased risk of developing lymphomas as compared with the general population. TNF-α antagonist therapy might be independently associated with an increased risk of lymphoma; however, other studies have shown that the risk of lymphoma is increased in RA patients with severe disease activity rather than the treatment per se. We experienced a 65-year-old woman who developed Etanercept–associated malignant lymphoma with rheumatoid arthritis. (Korean J Med 77:S1342-S1346, 2009)
Key Words: Etanercept; Malignant lymphoma; Rheumatoid arthritis


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