| Small cell carcinoma of the gall bladder: Two case reports |
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Myoung Hee Lee, Tae Jin Park, Hyun Woo Lee, Seok Yun Kang, Jin Hyuk Choi, Hugh Chul Kim, Hyunee Yim |
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경희대학교 의과대학 순환기내과학교실 |
| 증례 : 담낭 소세포암 2예 |
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이명희&#;박태진&#;이현우&#;강석윤&#;최진혁&#;김효철&#;임현이, Tae Jin Park, Hyun Woo Lee, Seok Yun Kang, Jin Hyuk Choi, Hugh Chul Kim, Hyunee Yim |
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| Abstract |
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Small cell carcinoma of the gallbladder is very rare, and represents about 5% or less of the total gallbladder cancer. This
rare pathological type of gall bladder cancer has a very poor prognosis requiring intensive adjuvant treatment. It presents
with highly malignant and devastating features, even with the adjuvant treatment.
We describe the two cases of small cell carcinoma in the gallbladder. A 68-year old woman suspicious of advanced
gallbladder cancer was admitted to our department for surgery. An radical cholecystectomy with retropancreatic lymph node
dissection was performed. After a pathological diagnosis, we started adjuvant chemotherapy (1,000 mg/m2 5-fluorouracil for
3 days; 100 mg/m2 etoposide for 3 days ; 25 mg/m2 cisplatin for 3 days; every 3 weeks). After 2-cycles of chemotherapy,
the patient refused all kinds of treatment because of nausea and vomiting. We followed the patient every 6 months and
there was no evidence of recurrence of the tumor by an abdominal US 4 years after surgery. Another 36-year old woman
suspicious of gallbladder cancer and cholecystitis, underwent a laparascopic cholecystectomy. After a pathological diagnosis,
the patient received 6-cycles of systemic chemotherapy (100 mg/m2 etoposide for 3days; 25 mg/m2 cisplatin, for 3 days;
every 3 weeks) and external irradiation to the gallbladder bed with a total dose of 4,000 cGy. There was no evidence of
recurrence of tumor by abdominal CT three months after surgery. We discuss the characteristics and treatment of this rare
tumor.(Korean J Med 73:S1022-S1028, 2007) |
| Key Words:
Small cell carcinoma, Gall bladder |
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