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The Korean Journal of Medicine 2007;73(4): 440-414.
원저 : 단백뇨가 동반된 성인 비박형 사구체 기저막 질환
신현주.심광연.박무용.최수정.김진국.황승덕.권계원, Kwang Yeon Shim, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Kye Won Kwon
The clinicopathological characteristics of thin basement membrane nephropathy with proteinuria in adult
Hyun Joo Shin, Kwang Yeon Shim, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Kye Won Kwon
경희대학교 의과대학 순환기내과학교실
Background : Proteinuria is rarely observed in patients who suffer from thin basement membrane nephropathy (TBMN). Our study was performed to evaluate the clinical characteristics and prognosis of TBMN patients with proteinuria. Methods : We conducted a retrospective study on 231 kidney biopsies. A urine protein level more than 500 mg for the 24-hour urine excretion was considered as significant proteinuria. We studied the clinical characteristics, the pathological findings and the response to treatment of these patients. Results : Ten (4 males and 6 females) of 17 cases of TBMN had significant proteinuria (59%). The mean patient age was 35 years. Six patients had hypertension and 1 patient had nephrotic syndrome. Two patients had proteinuria only, and 8 patients had both hematuria and proteinuria. At the time of biopsy, the amount of urine protein was 1,881 mg per day, and all the patients except one showed normal renal function. The GBM thickness ranged from 201 to 252 nm. Nine patients were treated with angiotensin receptor blocker, and 1 patient suffering from nephrotic syndrome was treated with prednisolone and cyclophosphamide. Marked improvement of the proteinuria (659 mg per day) was observed in 8 patients during the follow-up period. Conclusions : Thin basement membrane nephropathy is one of the causes of proteinuria. Therefore, reduction of the proteinuria should be considered for treating these patients.(Korean J Med 73:407-414, 2007)
Keywords: Thin basement membrane nephropathy, Proteinuria
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