| A case of metastatic malignant pheochromocytoma with partial remission after anthracycline-containing combination chemotherapy |
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고려대학교 의과대학 내과학교실 |
| 증례 : 복합 항암화학요법으로 부분 관해를 이룬 전이성 갈색세포종 환자 1예 |
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안재숙 |
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| Abstract |
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Pheochromocytoma is a neoplasm of the chromaffin tissue and about 10～15% of these tumors are malignant.
Although debulking surgery or medical treatment, including chemotherapy or radioiodine-labeled metaiodobenzylguanidine
(MIBG), are treatment options, there is currently no definitive management for metastatic pheochromocytoma.
The conventional therapeutic regimen has not shown clear survival benefit. We reported here on the first patient in Korea who had metastatic malignant pheochromocytoma that was effectively treated with ACVD (consisting of doxorubicin 40 mg/m2 D1, cyclophosphamide 750 mg/m2 D1, vincristine 1.4 mg/m2 D1 and dacarbazine 250 mg/m2 D1-5) combination chemotherapy. A 48-year-old woman underwent left adrenalectomy and nephrectomy for pheochromocytoma in March 2003. Eighteen months after the operation, multiple liver metastasis and local recurrence were found by abdominal CT scanning. The patient was given 8 courses of ACVD combination chemotherapy.
The side effects were grade 4 neutropenia without fever, grade 3 peripheral neuropathy and grade 2 diarrhea. After completion of 8 cycles of chemotherapy, the patient achieved a partial response and she's had no evidence of disease progression for over 1 year. (Korean J Med 72:S289-S293, 2007)
Key Words : Pheochromocytoma, Salvage therapy, Anthracyclines |
| Key Words:
Pheochromocytoma, Salvage therapy, Anthracyclines |
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