Two cases of seronegative, main pancreatic ductal narrowing, chronic pancreatitis that were responsive to short-term steroid treatment

Korean J Med > Volume 72(2); 2007 > Article

Original Article

The Korean Journal of Medicine 2007;72(2):103-109.

Two cases of seronegative, main pancreatic ductal narrowing, chronic pancreatitis that were responsive to short-term steroid treatment

고려대학교 의과대학 내과학교실

증례 : 단기 스테로이드 치료에 반응한 혈청음성 주췌관 협착성 만성췌장염 2예

이준영

Abstract

There is currently no widely accepted consensus on the diagnostic criteria for autoimmune pancreatitis, except for the diagnostic criteria announced in 2002 by the Japan Pancreas Society. This criteria state that if the characteristic radiologic findings and one or more of two criteria are met, then the diagnosis of autoimmune pancreatitis can be made. The characteristic radiologic findings are generalized edema of the pancreas with irregular generalized or segmental stenosis of the main pancreatic duct. The other two criteria are the presence of autoimmune antibodies or hypergammaglobinemia, and the histopathologic findings autoimmune pancreatitis namely, fibrosis and lymphocyte infiltration. Yet histologic examination is not possible for all patients and there have been reports of antibody negative autoimmune pancreatitis. In these cases, it can be difficult to diagnose autoimmune pancreatitis. We report here on two patients with suspected autoimmune pancreatitis that did not meet the Japan Pancreas Society criteria, but they responded to steroid treatment.(Korean J Med 72:S103-S109, 2007) Key Words : Autoimmune disease, Pancreatitis, Steroid

Key Words: Autoimmune disease, Pancreatitis, Steroid