Gastrointestinal tract (GIT) lymphomas usually originate from B-lymphocytes but rarely from
T-lymphocytes. The stomach is the most common site for extranodal GIT lymphoma but the
esophagus is a rare site. In addition, a primary esophageal T-cell lymphoma is an uncommon
disorder. We encountered a case of a primary esophageal T-cell lymphoma in a 60-year-old man,
who had swallowing difficulties and multiple ulcers in the upper and lower esophageal mucosa on
gastroscopy. Immunohistochemical staining for the biopsy material from the multiple esophageal
ulcers tested positive for LCA and CD45RO (pan T-cell marker) and negative for cytokeratin and
CD20 reactivity, respectively. No other abnormal lesions were observed on a computed tomography
scan of the neck, chest, abdomen and pelvis. After six cycles of combination chemotherapy with
cyclophosphamide, adriamycin, vincristin, prednisolone, etoposide and gemcitabine, the multiple
esophageal ulcers had completely disappeared suggesting a complete clinical response. We report this
case with a review of the relevant literature(Korean J Med 71:694-698, 2006)
Key Words : Esophagus, T-cell lymphoma
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