| Immunohistochemical Expression of c-erbB-2 and c-Met in Gastric Adenocarcinoma and Adenoma |
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연세대학교 의과대학 내과학교실 |
| Immunohistochemical Expression of c-erbB-2 and c-Met in Gastric Adenocarcinoma and Adenoma |
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Seung Woo Lee, Sang Beom Kang, . Yon Soo Kim, Soon Woo Nam, Dong Soo Lee, Hye Kyung Lee, Sok Won Han |
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| Abstract |
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Backgrounds/Aim : c-erbB-2 and c-met protooncogenes belong to a family of tyrosine kinase growth factor receptors.
Overexpression of these protooncogenes is often observed in various cancer tissues, especially in gastric carcinoma. The aim
of this study was to investigate the immunohistochemical expression of the c-erbB-2, c-met proteins according to the
histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM
stage in the gastric adenoma and adenocarcinoma. Methods : Immunohistochemical staining using monoclonal c-erbB-2, c-met
were performed on paraffin embedded specimens form 43 adenomas and 44 adenocarcinomas. Results : When compared to the
intensity observed in adjacent normal mucosal epithelial cells, the expression rate of c-erbB-2 is higher in gastric
adenomas(91%, 39/43) than in adenocarcinomas(30%, 13/44). The expression rate of c-met was higher in gastric
adenocarcinomas(77%, 34/44) than in adenomas(49%, 21/43). In adenomas c-met expression rate was higher in high grade
dysplasia(94%, 15/16) than in low grade dysplasia(22%, 6/27). In adenocarcinomas c-met expression was higher in lymph node
metastasis(89%, 25/28). Conclusions : It was suggested that c-met protein would be involved in gastric carcinogenesis, c-erbB-2
protein would be related with the development of gastric adenoma. The expression rate of c-met was significantly related with
lymph node metastasis. It was suggested that c-met protein might be involved in tumor progression, and so it may be
prognostic significance in gastric adenocarcinoma. |
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