Korean J Med > Volume 74(2); 2008 > Article
The Korean Journal of Medicine 2008;74(2):146-153.
Expression of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon
Eun Jung Cha, Kyu Yun Jang, Ha Na Choi, M.S., Kyung Ryul Kim, Keum Ha Choi, Sung Ho Hwang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee
서울대학교 의과대학 내과학교실1, 경희대학교 의과대학 내과학교실2
원저 : 결장 샘암종에서 Claudin-1, β-catenin과 E-cadherin의 발현
차은정 . 장규윤 . 최하나 . 김경열 . 최금하 . 황성호 . 문우성 . 강명재 . 이동, Kyu Yun Jang, Ha Na Choi, M.S., Kyung Ryul Kim, Keum Ha Choi, Sung Ho Hwang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee
Abstract
Background/Aims : Disruption of the cell-to-cell junction with changes in the expression of the junctional proteins is the hallmark of cancer invasion and metastasis. To investigate the roles of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon, the relationship of their expression with clinical and pathological factors were examined. Methods : The expression of claudin-1, β-catenin and E-cadherin were examined in 47 cases of adenocarcinoma of the colon by immunohistochemical staining. Results : A reduced claudin-1 expression was associated with advanced lymph node metastasis (p=0.019) and histological dedifferentiation at the invasive front (p=0.030). A reduced expression of β-catenin and E-cadherin were correlated with histological dedifferentiation (p=0.012, p=0.010, respectively). The reduced expression of two or more proteins was correlated with the histological findings of dedifferentiation (p=0.030). Conclusions : These results suggest that loss of claudin-1, β-catenin and E-cadherin expression may be correlated with the progression of adenocarcinoma of the colon and associated with an advanced histological grade.
Key Words: Colon; Adenocarcinoma; Claudin 1; beta Catenin; E-cadherins


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