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Cardiac malignant fibrous histiocytoma are extremely rare and the prognosis is reported to be very poor.
Here, we report a case of cardiac malignant fibrous histiocytoma with durable response by chemotherapy and thalidomide. A 35-year-old woman with sudden onset of dyspnea and chest pain was diagnosed with cardiac tumor. The tumor was removed by a supra-septal approach of open-heart surgery, and immunohistochemical staining revealed the malignant fibrous histiocytoma. However, we found the tumor recurrence at right atrium after 3 months. She was treated with systemic chemotherapy, and had partial response with significant treatment-related toxicities after 5-cycle chemotherapy. So we decided to do supportive care and thalidomide therapy, which is interested in studying as an anti-angiogenic agent recently. At present, patient still keep alive without the progression of disease for 18 months.(Korean J Med 70:S302-S308, 2006)
Key Words : Malignant fibrous histiocytoma, Thalidomide |
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