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Hepatitis-associated aplastic anemia is a variant of aplastic anemia in which aplastic anemia follows an acute attack of hepatitis. We recently experienced a case of post-hepatitis aplastic anemia. At the first vistit, the patient presented with acute hepatitis of unknown cause, which regressed spontaenously with supportive care. Two months later, the patient was readmitted with a complaint of petechiae on lower extremites. Blood test revealed a pancytopenia together with markedly decreased cellularitiy on bone marrow biopsy. The diagnosis of aplastic anemia was made. The symptom and sign did not respond to immunosuppressive treatment and then allogenic stem cell transplantation was performed. Despite the introduction of allogenic stem cell transplantation, the patient eventually died of multi-organ failure 9 day after the transplantation. In this case, we consider the possibility that acute hepatitis of unknown origin may lead to an acquired aplastic anemia.(Korean J Med 70:S141-S145, 2006)
Key Words : Hepatitis, Anemia, Aplastic, Immunosuppressive, Stem cell transplantation |
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