| Original Articles : Prevalence and clinical characteristics of microalbuminuria in Koreans : a population-based cross-sectional study |
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Eun Ran Kim, Ki Chul Sung, Chang Uk Chon, Chang Hee Kwon, Young Lyul Koh, Hyun Jong Lee, Sung Kun Park, Do Young Lee, Ji Ho Yun, Byung Jin Kim, Bum Soo Kim, Jin Ho Kang, Man Ho Lee, Jung Ro Park, Seung Ho Ryu |
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한림의대 한강성심병원 내과 |
| 원저 : 한국인에서 미세단백뇨의 유병률 및 임상적 특성 |
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김은란, Ki Chul Sung, Chang Uk Chon, Chang Hee Kwon, Young Lyul Koh, Hyun Jong Lee, Sung Kun Park, Do Young Lee, Ji Ho Yun, Byung Jin Kim, Bum Soo Kim, Jin Ho Kang, Man Ho Lee, Jung Ro Park, Seung Ho Ryu |
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| Abstract |
Background : Microalbuminuria (MA) is independent predictor of cardiovascular disease and it cause mortality regardless of the presence of diabetes (DM) and hypertension (HTN). However, few published studies on this topic have been reported in Korea. Therefore, we investigated the MA prevalence and relationship between MA, insulin resistance and cardiovascular risk factor.
Methods
: A total of 5,915 (3,053 men and 2,852 women) health screen examinees were enrolled in this study. We measured the anthropometric and biochemical parameters of the atherogenic indexes.
Results
: The MA prevalence was 7.7% in all participants. The prevalence of MA in the men and women was 9.5% and 5.7%, respectively. Elevated levels of serum fasting glucose, serum fasting insulin, HOMA index, total cholesterols, LDL cholesterol, TG, Body Mass Index (BMI) and the systolic and diastolic blood pressure were significantly associated with MA. The results of multiple logistic regression analysis about MA showed that frequent drinking, low BMI, newly diagnosed DM and elevated levels of HOMA index and blood pressure were significantly associated with MA prevalence. Also, excluding newly diagnosed diabetic and hypertensive subjects, the MA prevalence was 5.7% (6.9% in men, 4.7% in women) and in multiple logistic regression analysis, the MA prevalence significantly increased in the individuals with pre-HTN rather than in the normotensives.
Conclusions
: The MA prevalence was 7.7% in all subjects. Except the newly diagnosed diabetic and hypertensive subjects, it was 5.7%. The MA prevalence was significantly increased in the individuals with pre-HTN rather than in the normotensives and MA was related with insulin resistance.(Korean J Med 70:617-626, 2006)
Key Words : Microalbuminuria, Hypertension, Prehypertension, Insulin resistance |
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