Sudden Deafness in a Patient with Chronic Hepatitis C Treated with Peginterferon and Ribavirin Combination Therapy |
Gun Woo Park1, Hyoung Yeol Park1, Eui Kyeong Bang2, Jun Ho Jo1, Min Woong Jeong1, Song Hee Oh1 |
1Departments of Internal Medicine, Busan Veterans Hospital, Busan, Korea 2Departments of Otolaryngology, Busan Veterans Hospital, Busan, Korea |
페그 인터페론과 리바비린 투여 후 발생한 돌발성 난청 1예 |
박건우1, 박형열1, 방의경2, 조준호1, 정민웅1, 오송희1 |
1부산보훈병원 내과 2부산보훈병원 이비인후과 |
Correspondence:
Gun Woo Park, Tel: +82-51-601-6000, Fax: +82-51-601-6339, Email: z-zone13@hanmail.net |
Received: 27 February 2014 • Revised: 7 April 2014 • Accepted: 28 August 2014 |
|
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Abstract |
Combined peginterferon and ribavirin therapy for chronic hepatitis C is associated with several adverse side effects, but sudden deafness is uncommon. Here we report the case of a 62-year-old female with chronic hepatitis C (genotype 1b) who developed sud-den deafness after completing 12 months of treatment with peginterferon α2a (180 μg/week) and ribavirin (1,000 mg/day). Pure-tone audiometry revealed a right-sided sensorineural hearing loss, which did not respond to 2 weeks of systemic corticosteroid therapy. Six months after the end of treatment for chronic hepatitis C, her qualitatively determined hepatitis C virus RNA level was 121,000 IU/mL. Following therapeutic failure, the patient was observed without retreatment for chronic hepatitis C or her hearing loss for a period of 12 months, during which time her hearing recovered almost completely. |
Key Words:
Hepatitis C, Chronic; Peginterferon alfa-2a; Ribavirin; Hearing loss, Sudden |
주제어:
만성 C형 간염; 페그 인터페론 알파 2a; 리바비린; 돌발성 난청 |
|