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Korean J Med > Volume 88(3); 2015 > Article
The Korean Journal of Medicine 2015;88(3): 288-292.
페그 인터페론과 리바비린 투여 후 발생한 돌발성 난청 1예
박건우1, 박형열1, 방의경2, 조준호1, 정민웅1, 오송희1
1부산보훈병원 내과
2부산보훈병원 이비인후과
Sudden Deafness in a Patient with Chronic Hepatitis C Treated with Peginterferon and Ribavirin Combination Therapy
Gun Woo Park1, Hyoung Yeol Park1, Eui Kyeong Bang2, Jun Ho Jo1, Min Woong Jeong1, Song Hee Oh1
1Departments of Internal Medicine, Busan Veterans Hospital, Busan, Korea
2Departments of Otolaryngology, Busan Veterans Hospital, Busan, Korea
Corresponding Author: Gun Woo Park ,Tel: +82-51-601-6000, Fax: +82-51-601-6339, Email: z-zone13@hanmail.net
Received: February 27, 2014;   Revised: April 7, 2014;   Accepted: August 28, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Combined peginterferon and ribavirin therapy for chronic hepatitis C is associated with several adverse side effects, but sudden deafness is uncommon. Here we report the case of a 62-year-old female with chronic hepatitis C (genotype 1b) who developed sud-den deafness after completing 12 months of treatment with peginterferon α2a (180 μg/week) and ribavirin (1,000 mg/day). Pure-tone audiometry revealed a right-sided sensorineural hearing loss, which did not respond to 2 weeks of systemic corticosteroid therapy. Six months after the end of treatment for chronic hepatitis C, her qualitatively determined hepatitis C virus RNA level was 121,000 IU/mL. Following therapeutic failure, the patient was observed without retreatment for chronic hepatitis C or her hearing loss for a period of 12 months, during which time her hearing recovered almost completely.
Keywords: Hepatitis C, Chronic; Peginterferon alfa-2a; Ribavirin; Hearing loss, Sudden
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