| Long-term complete remission in a patient with colonic multiple lymphomatous polyposis treated with R-CHOP combination chemotherapy |
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Gun Min Kim, Hae Mi Lee, Ja Young Kim, An Hi Lee, Byung Wook Kim, Kyu Yong Choi, Chi Wha Han |
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| 대장의 다발성 림프종양 용종증 환자에서 R-CHOP 병용화학치료 후 얻어진 장기 완전관해 |
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김건민, 이해미, 김자영, 이안희, 김병욱, 최규용, 한치화 |
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| Abstract |
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Multiple lymphomatous polyposis (MLP) is a rare form of primary gastrointestinal non-Hodgkin’s lymphoma that is regarded as an intestinal counterpart of mantle cell lymphoma (MCL) by REAL classification. However, MLP may appear as other histological types, including mucosa-associated lymphoid tissue or follicular, angioimmunoblastic, or T-cell lymphoma. MCL treated with conventional chemotherapy has a poor prognosis. Treatment outcome can be improved by high-dose chemoradiotherapy with autologous hematopoietic stem cell support following induction chemotherapy or addition of the chimeric anti-CD20 monoclonal antibody, rituximab. We report a 55-year-old woman with mantle-cell-lymphoma-type MLP that involved the rectum and bone marrow. Immunohistochemical staining of tumor tissue revealed that CD20, CD5, and cyclin D1 were positive, whereas CD10 was negative. After six courses of R-CHOP, the patient was in complete histological remission, which has remained for >26 months. |
| Key Words:
Multiple intestinal polyposis; Mantle cell lymphoma; Rituximab |
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