| A Case of Acute Tubular Necrosis and Hearing Loss Induced by Intravenous Administration of Ciprofloxacin |
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Jun Jae Kim1, Hyun-Jung Kim2, Sang Hyun Kim1, Won Do Park1 |
1Departments of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
2Departments of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea |
| 시프로플록사신 정맥 주사 후 발생한 급성 요세관 괴사와 청력 소실 1예 |
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김준재1, 김현정2, 김상현1, 박원도1 |
1인제대학교 의과대학 상계백병원 내과
2인제대학교 의과대학 상계백병원 병리과 |
Correspondence:
Sang Hyun Kim, Tel: +82-2-950-1353, Fax: +82-2-950-1955, Email: shkim@paik.ac.kr
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Received: 1 February 2013 • Revised: 15 March 2013 • Accepted: 23 May 2013 |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/bync/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Abstract |
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Ciprofloxacin is a broad-spectrum antibiotic used to treat a variety of infections. However, acute kidney injury is a rarely reported side effect. Ciprofloxacin-related nephrotoxicity typically manifests as acute tubulointerstitial nephritis. To the best of our knowledge, few cases of acute tubular necrosis as a complication of ciprofloxacin have been reported to date. We herein describe a case involving a 41-year-old woman treated with intravenous ciprofloxacin at 200 mg twice daily for gastroenteritis. One day after initiation of treatment, her serum creatinine level increased from 0.95 to 3.83 mg/dL and she experienced impaired hearing. Five days later, renal biopsy demonstrated acute tubular necrosis. The acute tubular necrosis encountered in this patient resolved; however, short-term hemodialysis was required. This is the first reported case of acute kidney injury associated with ciprofloxacin use in Korea. |
| Key Words:
Ciprofloxacin; Acute kidney injury; Acute tubular necrosis; Hearing loss |
| 주제어:
시프로플록사신; 급성신질환; 급성 요세관 괴사; 청력 소실 |
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