Regression of colon polyposis after aspirin medication

So Young Choi,; Hyun Seok Lee,; Soo Young Park,; Min Kyu Jung,; Seong Woo Jeon,; Sung Kook Kim,

Korean J Med > Volume 78(4); 2010 > Article

Original Article

The Korean Journal of Medicine 2010;78(4):485-489.

Regression of colon polyposis after aspirin medication

So Young Choi, Hyun Seok Lee, Soo Young Park, Min Kyu Jung, Seong Woo Jeon, Sung Kook Kim

아스피린 복용 후 소실된 대장 용종증

최소영, 이현석, 박수영, 정민규, 전성우, 김성국

Abstract

There is considerable evidence that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk of colorectal neoplasia. Unlike cyclooxygenase-1 (COX-1), which is constitutively expressed in the colon, COX-2 is overexpressed in colorectal cancers and adenomas in human. Aspirin inhibits the generation of prostaglandins by inhibiting both COX-1 and COX-2, which initiate prostaglandin synthesis. The chemopreventive effect of aspirin against the development of colorectal adenomas has been widely investigated. However, there is no agreement on the effect of aspirin on existing adenomas. We describe a case of colon polyposis that disappeared after aspirin medication.

Key Words: Aspirin; Colon; Polyp