Korean J Med > Volume 75(6); 2008 > Article
The Korean Journal of Medicine 2008;75(6):718-722.
Rhabdomyolysis due to hyponatremia in a patient taking benzodiazepines
Jae Hyeok Jeong, Jae Hyun Cho, Chang Min Yu, Seong-O Suh, Seok Jin Ahn, Jun-Oh Jung, Youn Kwon Kim
경희대학교 의과대학 순환기내과학교실
벤조디아제핀 복용 중 발생한 저나트륨혈증에 의한 횡문근융해증 1예
정재혁, 조재현, 유창민, 서승오, 안석진, 정준오, 김윤권
Abstract
Hyponatremia is rarely reported to cause rhabdomyolysis and there has been only one case report on rhabdomyolysis due to hyponatremia, possibly complicated by benzodiazepines. We experienced a case of rhabdomyolysis due to hyponatremia during the use of benzodiazepines in a patient with an acute psychosis. A 60-year-old man was admitted to the emergency room due to altered mentality. He had been taking benzodiazepines for 1 month because of insomnia, uneasiness, and depression. His initial blood chemistry revealed severe hypotonic hyponatremia in the absence of polydipsia, edema, and features of dehydration. While correcting the hyponatremia, rhabdomyolysis developed with no evidence of trauma, seizures, or tremor. In patients with acute psychosis, the development of rhabdomyolysis due to hyponatremia or its correction should not be underestimated and should be assessed thoroughly. Clinicians also need to be aware of the potential risk of benzodiazepines for the development of rhabdomyolysis. (Korean J Med 75:718-722, 2008)
Key Words: Rhabdomyolysis; Hyponatremia; Benzodiazepines


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