| Microscopic polyangiitis presenting as peripheral neuropathy |
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Sung-Guon Hong, Jae-Young Yoon, Ju-Ie Park, Sung-Yang Min, So-Ya Bak, Hyun-Jung Ryu, Hyo-Jong Kang |
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경희대학교 의과대학 순환기내과학교실 |
| 증례 : 말초신경병증으로 발현된 현미경적 다발성 혈관염 1예 |
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홍승권, 윤재영, 박주이, 민선양, 백소야, 유현정, 강효종 |
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| Abstract |
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Microscopic polyangiitis (MPA) is a systemic small vessel (arteriole, venule, capillary) vasculitis with few or no immune deposits and no granulomatous inflammation. It may be difficult to differentiate between PAN (polyarteritis nodosa) and MPA simply based on clinical data. However, the presence or absence of antineutrophil cytoplasmic antibody (ANCA), findings on visceral angiography, and biopsy from involved organs are helpful adjuncts toward diagnosing MPA or PAN. Peripheral neuropathy may be the initial manifestation of MPA, and it occurs in approximately 20～30% of patients with MPA. We report the case of a 65-year-old woman who presented with paresthesias and motor weakness of the extremities and who was later diagnosed with MPA based on the findings of positive P-ANCA and negative angiography, along with findings on sural nerve biopsy. We did not find any evidence of kidney or lung involvement. We followed the patient for over two years, and her course was benign after initiation of immune-modulating therapy. |
| Key Words:
Microscopic polyangiitis; Polyarteritis nodosa; Peripheral neuropathy |
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