| A case of alpha heavy-chain renal amyloidosis associated with multiple myeloma |
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Yoon Hee Jun, Seo Eun Bae, Jung-Hwa Ryu, Dong-Ryeol Ryu, Soon Hee Sung, Ki Sook Hong, Soon Nam Lee |
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성균관대학교 의과대학 삼성서울병원 심장혈관센터 순환기내과 |
| 증례 : 다발성 골수종과 동반된 alpha 중쇄 신유전분증 1예 |
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전윤희&#;배서은&#;류정화&#;류동열&#;성순희&#;홍기숙&#;이순남, Seo Eun Bae, Jung-Hwa Ryu, Dong-Ryeol Ryu, Soon Hee Sung, Ki Sook Hong, Soon Nam Lee |
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| Abstract |
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Amyloidosis is a disease characterized by the extracellular deposition of amyloid in various tissues and organs,
especially the kidney and heart. In patients with multiple myeloma, many factors contribute to the development of renal
impairment including hypercalcemia, recurrent infections and the infiltration of myeloma cells as well as glomerular
deposits of amyloid. We treated a case of alpha heavy-chain renal amyloidosis in a 54 year-old woman. The patient was
admitted with generalized edema for 10 days, and was known to have the nephrotic syndrome. Renal biopsy was
undertaken and the diagnosis of renal amyloidosis was made. Although she did not have bony lesions, anemia and
hypercalcemia, the results of the serum and urine protein electrophoresis showed an M-peak, and multiple myeloma was
confirmed by a bone marrow biopsy. We report herein a very rare case of alpha heavy-chain amyloidosis associated with
multiple myeloma and review the medical literature.(Korean J Med 73:S1003-S1007, 2007) |
| Key Words:
Amyloidosis, Alpha heavy-chain, Multiple myeloma |
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