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Korean J Med > Volume 88(5); 2015 > Article
The Korean Journal of Medicine 2015;88(5): 518-524.
침습성 진균 감염증과 약제 내성
김어진, 정숙인
전남대학교 의과대학 내과학교실
Invasive Fungal Infections in the Era of Antifungal Resistance
Uh Jin Kim, Sook-In Jung
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
Corresponding Author: Sook-In Jung ,Tel: +82-62-220-6502, Fax: +82-62-225-8578, Email: sijung@chonnam.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Invasive fungal diseases are an important cause of morbidity and mortality in both immunocompromised and immunocompetent patients. The recent introduction of new antifungal agents seemed to open a new era for the treatment of invasive fungal infections. However, widespread use of prophylactic and therapeutic antifungal agents has lead to the emergence of antifungal resistance and potentially compromises their clinical utility. By understanding the mechanisms of drug resistance, new strategies can be utilized to minimize the emergence of drug resistance and to promote the development of innovative therapeutic approaches. In the meantime, close monitoring of antifungal resistance and its evolution is warranted in a clinical setting given the limited repertoire of antifungal drugs.
Keywords: Antifuangals; Resistance; Invasive fungal infection
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