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Korean J Med > Volume 88(3); 2015 > Article
The Korean Journal of Medicine 2015;88(3): 350-355.
전신경화증과 류마티스 관절염의 중복 증후군 3예
이슬기, 유쾌한, 이걸, 김인영, 권희진, 정혜민, 고은미
성균관대학교 의과대학 삼성서울병원 내과
Three Cases of Overlap Syndrome Consisting of Systemic Sclerosis and Rheumatoid Arthritis
Seulkee Lee, Kwai Han Yoo, Keol Lee, In Young Kim, Hee Jin Kwon, Hyemin Jeong, Eun-Mi Koh
Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: Eun-Mi Koh ,Tel: +82-2-3410-3433, Fax: +82-2-3410-3849, Email: emkoh@skku.edu
Received: June 4, 2014;   Revised: July 21, 2014;   Accepted: September 3, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Overlap syndrome is defined as a disease entity that fulfills the classification criteria of at least two different rheumatologic diseases simultaneously. Overlap of systemic sclerosis (SSc) and rheumatoid arthritis (RA) is less common than the overlap of polymyositis with SSc or systemic lupus erythematosus. Distinguishing RA from SSc can be difficult because arthralgia is a frequent symptom of both. We observed three cases of RA and SSc overlap. In each case, RA occurred in sequence with SSc, with a period of 4-15 years between the onset of each disease. In one case, the patient had diffuse SSc, which is rare among overlap syndrome patients. Previously, only one case of overlap syndrome involving SSc and RA has been reported in Korea; herein, we report our cases with a review of the literature.
Keywords: Systemic sclerosis; Rheumatoid arthritis
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