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Korean J Med > Volume 87(1); 2014 > Article
The Korean Journal of Medicine 2014;87(1): 42-52.
투석 환자에서 혈관 석회화, 동맥 경직, 염증, 영양 상태와의 상관관계
신선영, 한규현, 정혜윤, 추지민, 김홍민, 서성은, 현여경, 김형종
차의과학대학교 분당차병원 내과학교실
Vascular Calcification Scores are Associated with Arterial Stiffness, Inflammation, and Nutrition in Hemodialysis Patients
Sun Young Shin, Kyu Hyun Han, Hye Yun Jeong, Ji Min Chu, Hong-Min Kim, Seongeun Suh, Yukyung Hyun, Hyung-Jong Kim
Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea
Corresponding Author: Hyung-Jong Kim ,Tel: +82-31-780-5895, Fax: +82-31-780-5898, Email: khj04@cha.ac.kr
Received: December 4, 2013;   Revised: January 16, 2014;   Accepted: March 3, 2014.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Background/Aims: The vascular calcification (VC) score on a plain X-ray is associated with cardiovascular disease and mortality in hemodialysis (HD) patients. This study examined the correlations among the VC scores for the hands and pelvis X-rays, arterial stiffness, inflammation, and nutrition in HD patients.
Methods:
VC was evaluated using plain x-rays of the hands and pelvis. Patients were categorized into the VC (+) (VC score ≥ 3) or VC (-) (VC score < 3) groups. We measured the pulse wave velocity (PWV), ankle brachial index (ABI), and augmentation index (AI).
Results:
The mean age of the patients was 55.6 ± 13.2 years. The prevalence of diabetes mellitus (DM) was significantly higher in the VC (+) group than in the VC (-) group (87.5 vs. 34.2%, p < 0.05). The serum PTH (98.4 ± 141.9 vs. 183.6 ± 231.3 pg/mL, p < 0.05) and albumin (3.7 ± 0.5 vs. 3.9 ± 0.3 g/dL, p < 0.05) levels were significantly lower and PWV was significantly (p < 0.05) higher in the VC (+) group. In multiple linear regression analysis, only the presence of diabetes mellitus was significantly related to the VC score.
Conclusions:
The VC score was associated with the serum PTH and albumin, as well as with vascular stiffness. C-reactive protein did not show any significant association with the VC score.
Keywords: Vascular calcification; Vascular stiffness; Pulse wave analysis; Hemodialysis
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Factors Associated with Quality Control of Hemodialysis Treatment  2014 October;87(4)
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