A case of diabetic ketoacidosis associated with long-term risperidone use

In-Joung Lee,; Hyun-Sung Kim,; Jun Goo Kang,; Chul Sik Kim,; Sung-Hee Ihm,; Hyung Joon Yoo,; Seong Jin Lee,

Korean J Med > Volume 77(5); 2009 > Article

Original Article

The Korean Journal of Medicine 2009;77(5):1212-1216.

A case of diabetic ketoacidosis associated with long-term risperidone use

In-Joung Lee, Hyun-Sung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Hyung Joon Yoo, Seong Jin Lee

장기간 risperidone 복용 후 발생한 당뇨병성 케톤산증 1예

이인정·김현성·강준구·김철식·임성희·유형준·이성진, Hyun-Sung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Hyung Joon Yoo, Seong Jin Lee

Abstract

The atypical antipsychotics used to treat patients with schizophrenia may cause many metabolic problems, such as weight gain, hyperlipidemia, diabetes mellitus (DM) and, rarely, diabetic ketoacidosis (DKA). We report the first case of new-onset type 2 DM and DKA associated with long-term risperidone use in Korea. A 42-year-old man visited our hospital complaining of polydipsia, polyuria, polyphagia, generalized weakness, and weight loss. He had been taking risperidone (4 mg/day) to treat schizophrenia for 7 years. Based on laboratory tests, dyslipidemia and new-onset type 2 DM accompanied by DKA were diagnosed. He was treated immediately with intravenous hydration and insulin therapy, and recovered completely. When treating patients with risperidone, it is important to monitor their weight, blood pressure, fasting blood glucose, and lipid profile carefully because risperidone may lead to type 2 DM or, rarely, DKA. (Korean J Med 77:S1212-S1216, 2009)

Key Words: Diabetes mellitus; Diabetic ketoacidosis; Antipsychotic agents