| Two cases of imported paratyphoid fever with poor response to ciprofloxacin following travel to India |
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Song Yi Kim, Nam Seok Lee, Jin Kyu Noh, Yong Hwan Kwon, Sang Hoon Han, Young Uh, Hyo Youl Kim |
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| Ciprofloxacin에 불량한 치료반응을 보인 인도 유입형 파라티푸스 2예 |
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김송이, 이남석, 노진규, 권용환, 한상훈, 어 영, 김효열 |
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| Abstract |
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It is well known that paratyphoid fever is caused by Salmonella enterica serotype paratyphi (S. paratyphi) and usually responds to ciprofloxacin treatment. Recently, many reports have recommended that S. paratyphi with nalidixic acid resistance should be considered if paratyphoid fever does not improved with ciprofloxacin treatment. We experienced two patients who were diagnosed with paratyphoid fever after traveling to India. The paratyphoid fever was caused by ciprofloxacin-susceptible and intermediate S. paratyphi infection; however, the patients became refractory to treatment with ciprofloxacin. After 7 days of treatment with ciprofloxacin, we changed the antibiotic treatment to a third-generation cephalosporin. Sustained fever and watery diarrhea was improved within 3 days after changing the antibiotics. In uncomplicated cases of paratyphoid fever, an adequate dose of ciprofloxacin can be given initially. If clinical improvement is not noted after 3 to 5 days, however, third-generation cephalosporins should be considered as an alternative regimen. |
| Key Words:
Cephalosporins; Ciprofloxacin; Paratyphoid fever |
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