| Lymphocytic infundibuloneurohypophysitis presenting with central diabetes insipidus: a case report and review of previous Korean cases |
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Seong Rheol Oh, Jeong Min Cha, Ae Ryoung Jin, Jong Bin Park, Ha Young Kim, Byoung Hyun Park, Chung Gu Cho |
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| 중추성 요붕증을 보인 림프구성 누두신경뇌하수체염 1예 - 1예 보고 및 기존 국내 보고 증례들의 검토- |
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오성렬, 차정민, 진애령, 박종빈, 김하영, 박병현, 조정구 |
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| Abstract |
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Lymphocytic infundibuloneurohypophysitis is a neuroendocrine disorder characterized by autoimmune inflammation of the pituitary stalk and neurohypophysis. Clinical findings such as acute onset central diabetes insipidus and the regression of characteristic magnetic resonance imaging (MRI) findings allow for the possible diagnosis of this disease.
Three cases of lymphocytic infundibuloneurohypophysitis have been previously reported in Korea. Here we report a case in a 66-year-old woman, along with a review of previously reported occurrences in Korea.
A woman presented with abrupt-onset central diabetes insipidus. Sella MRI showed thickening of the pituitary stalk and loss of high T1 signals that are associated with a normal neurohypophysis. Basal pituitary hormone levels were normal with the exception of growth hormone, which was low. The patient refused transsphenoidal pituitary biopsy and we thus chose to continue close clinical and radiologic follow-up after desmopressin nasal spray application. The need for desmopressin decreased slightly over time and MRI obtained after 6 months showed regression of the pituitary stalk lesion. |
| Key Words:
Diabetes insipidus; Central; MRI scans; Pituitary gland; Posterior |
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