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The Korean Journal of Medicine 2009;77(4): 512-516.
임신 3분기 중 발현된 요붕증
이수희, 원현선, 류현미, 박소영, 김성훈, 한기옥, 윤현구
Gestational diabetes insipidus in the third trimester of pregnancy
Su-Hee Lee, Hyun-Sun Won, Hyun-Mee Ryu, So-Young Park, Sung-Hoon Kim, Ki-Ok Han, Hyun-Koo Yoon
Gestational diabetes insipidus, which occurs rarely during late pregnancy, may injure the mother and fetus neurologically. It takes place in about 4 of every 100,000 pregnancies. Increased placental-derived vasopressinase in late pregnancy markedly degrades vasopressin. The decreased vasopressin activity causes hypotonic polyuria, polydipsia, and dehydration. We report a woman with gestational diabetes insipidus who had no abnormal laboratory tests before developing symptoms. The diabetes insipidus was controlled well by administering nasal desmopressin (1‐desamino‐8‐D‐arginine vasopressin, DDAVP) followed by resolution of the signs and symptoms after delivery. Although gestational diabetes insipidus is rare, a prompt diagnosis and appropriate treatment to reduce the risks of maternal and fetal injury are important. (Korean J Med 77:512-516, 2009)
Keywords: Desmopressin; Gestational diabetes insipidus; Vasopressinase
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New strategies in the treatment of hypertension  2009 April;76(4)
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