| A longitudinal study on the relationship between methacholine airway hyperresponsiveness and exercise-induced bronchoconstriction |
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Chang-Seong Kim, Inseon S. Choi, Sang-Hoon Kim, Hak Woo, Hyeon-Jeong Sim, Eui-Ryoung Han |
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| 메타콜린과 운동 유발 기관지 수축반응의 상관관계에 대한 종단적 연구 |
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김창성, 최인선, 김상훈, 우 학, 심현정, 한의령 |
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| Abstract |
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Background/Aims: The airway hyperresponsiveness (AHR) in asthma has variable and persistent components that are related to
airway inflammation and remodeling, respectively. This longitudinal study examined the relationship of airway responses between
exercise (reflecting variable AHR) and methacholine (reflecting persistent AHR).
Methods: The charts were reviewed of 36 young adult males who underwent both methacholine and exercise challenges at different
times and were diagnosed with exercise-induced asthma. The severity of the response to each stimulus was scored (0~3).
Results: The mean interval between the baseline and follow-up tests was 9.8 (5~58) months. The AHR score was significantly
lower with the exercise challenge than with methacholine at follow-up (1.58±0.16 vs 1.19±0.15, p<0.01), but not at baseline.
Compared to baseline, the AHR score was significantly lower with exercise (1.67±0.13 vs 1.19±0.15, p<0.01), but not with methacholine,
and the difference in the AHR scores between exercise and methacholine increased significantly from baseline to follow-
up (0.03±0.13 vs 0.39±0.13, p<0.05). The maximum fall in the forced expiratory volume in 1 s following exercise was significantly
related to methacholine AHR (r=-0.571, p<0.001).
Conclusions: Exercise-induced bronchoconstriction was significantly related to methacholine AHR. However, the change in
methacholine AHR in a follow-up test was significantly lower than that in the exercise response, which might have resulted from
persistent worsening of the AHR with time because methacholine AHR reflects both variable and persistent AHR. (Korean J Med
77:472-479, 2009) |
| Key Words:
Asthma; Exercise; Methacholine; Variable |
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