IgA nephropathy is characterized by the predominant deposition of IgA in a granular fashion diffusely in the mesangial zones of
glomeruli. IgA nephropathy was first described over four decades ago and is now the most common form of primary glomerular
disease. Much progress has been made in the elucidation of potential pathogenetic mechanisms such as undergalactosylated IgA1 as
well as in the fields of clinical features, prognosis, and treatment. This knowledge is being applied in the development of new diagnostic
methods
and hopefully in the future the creation of novel and rational therapeutic approaches. (Korean J Med 77:435-443,
2009) |
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