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The Korean Journal of Medicine 2008;75(4): 370-382.
특집: 약물방출 스텐트의 최근 동향
김성환.홍명기,
Current status of drug-eluting stents
Sung-Hwan Kim, Myeong-Ki Hong
성균관 의과 대학교 삼성 서울 병원 심혈관 센터 순환기 내과
ABSTRACT
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea The percutaneous coronary intervention (PCI) has been a great advance in the treatment of coronary artery disease since implantation of bare metal stents (BMS) decreased acute recoil and arterial shrinkage caused by balloon angioplasty. However, neointimal hyperplasia leading to in-stent restenosis after BMS implantation has been emerged a new obstacle. Recent introduction of drug-eluting stents (DES) contributes a powerful breakthrough to PCI. Many large well-controlled randomized trials have shown that DES remarkably reduces restenosis and target vessel revascularization in de novo lesions when compared with BMS. Therefore the application of DES have been expanded to the complex lesions such as left main, multi-vessel, bifurcation, in-stent restenosis, or chronic total occlusion. The safety and effectiveness of DES are still under evaluation with ongoing trials. However, some problems such as very late stent thrombosis remained to be solved. In this review article, we summarize the past, present and future of DES with updated result of clinical trials. (Korean J Med 75:370-382, 2008)
Keywords: Drug-eluting stents; Percutaneous transluminal coronary angioplasty
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