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The Korean Journal of Medicine 2008;74(6): 640-647.
원저 : Mycophenolate Mofetil과 Cyclophosphamide의 증식성 루푸스 신염 치료 효과 비교
문성진, 김동기, 박선영, 장제현, 김현욱, 이정은, 한승혁, 고광일, 김동현, 김찬호, 이상원, 김범석, 강신욱, 한대석, 이호영, 박용범, 이수곤, 최규헌
A comparison study between mycophenolate mofetil and cyclophosphamide for reatment of proliferative lupus nephritis
Sung Jin Moon, Dong Ki Kim, Sun Young Park, Jae Hyun Chang, Hyun-Wook Kim, Jung Eun Lee, Seung Hyeok Han, Kwang Il Ko, Dong Hyun Kim, Chan Ho Kim, Sang Won Lee, Beom Suk Kim, , , , , ,
Department of Pulmonology and Critical Care Medicine, Chonnam National University Medical School, Gwangju, Korea
Background/Aims : Our study aimed to evaluate the efficacy of MMF as compared with intravenous cyclophosphamide as induction therapy for proliferative lupus nephritis in Koreans. Methods : Forty-three patients who were diagnosed with proliferative lupus nephritis (WHO Class III and IV) between Jan 2000 and Dec 2006 were included in this study. Nineteen patients were treated with oral MMF (initial dose: 1.0 g/day and then it was increased to 2.0 g/day) and 24 patients were treated with 0.75-1.0 g/m2 of monthly intravenous cyclophosphamide (CP) followed by subsequent treatment with oral corticosteroid (initial dose 1 mg/kg/day and then it was slowly tapered down) for 6 months. The demographic and laboratory findings, the response rate and the adverse events were reviewed retrospectively and these were compared between the two groups. Results : A complete response occurred in 7 out of the 19 patients (36.8%) treated with MMF and in 8 out of the 24 patients (33.3%) treated with CP, and the difference was not significantly different between the two groups (p=0.66). A partial response was achieved in 52.6% and 45.8%, respectively. There were no significant differences of the laboratory findings such as serum albumin, C3, C4, the urine protein/creatinine ratio and serum creatinine after treatment for 6 months. In addition, both groups had similar rates of adverse events. Conclusions : Our study showed that for the treatment of lupus nephritis, MMF was as effective as IV cyclophosphamide with similar adverse events. This finding suggests that MMF could be an alternative treatment for active lupus nephritis as induction therapy.
Keywords: Lupus nephritis; Mycophenolate mofetil; Cyclophosphamide
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