| Intravenous Anti-D immunoglobulin treatment of adult chronic immune thrombocytopenic purpura (ITP) |
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Hye-Jeong Kim, Yunjin Jung, Eui Nam Hwang, Young-Hoon Kim, Jin Sung Choi, Seung-Hyun Nam, Bong-Seog Kim, Do Yeon Oh, Sung Soo Yoon, Sun Yang Park |
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서울적십자병원 내과 |
| 원저 : 만성면역혈소판감소자색반에서의 Anti-D immunoglobulin 치료 |
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김혜정 . 정윤진 . 황의남 . 김영훈 . 최진성 . 남승현 . 김봉석 . 오도연 . 윤성, Yunjin Jung, Eui Nam Hwang, Young-Hoon Kim, Jin Sung Choi, Seung-Hyun Nam, Bong-Seog Kim, Do Yeon Oh, Sung Soo Yoon, Sun Yang Park |
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| Abstract |
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Background/Aims : Immune thrombocytopenic purpura (ITP) is an autoimmune disease that is mediated by anti-platelet antibodies. Based on the pathogenesis of ITP we evaluated the efficacy of intravenous anti-D immunoglobulin for adult chronic ITP.
Methods : Fourteen patients (4 without splenectomy and 10 with splenectomy) with refractory chronic ITP were treated with 50-70μg/kg of intravenous anti-D immunoglobulin only once. Treatment effects were evaluated by measuring the platelet counts and hemoglobin levels.
Results : Five patients (36%) showed a response; improvement in the platelet count lasted for on average 7 days (range: 2～24 days). There were no serious adverse effects.
Conclusion : Anti-D immunoglobulin, which is associated with an Fc receptor blockade, appeared to be safe and effective for the treatment of adults with chronic ITP. Further studies are needed to confirm these findings and define further potentially effective treatment protocols with intravenous anti-D immunoglobulin.
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| Key Words:
immune thrombocytopenic purpura; Fc receptor blockade; Anti-D-immunoglobulin |
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