| The type and incidence of malignancy in 1500 renal transplant recipients at Kangnam St. Mary's Hospital |
|
Jin Young Kim, Jennifer Lee, Sung Eun Lee, Su Hyun Kim, Bum Soon Choi, In Sung Moon, Chul Woo Yang, Yong Soo Kim, Yong Bok Koh, Byung Kee Bang |
|
국립경찰병원 내과, 진단검사의학과2 |
| 원저 : 신장이식환자에서 발생한 악성종양의 종류와 발병율 양상 |
|
김진영, 이주하, 이성은, 김수현, 최범순, 문인성, 양철우, 김용수, 고용복, 방병기 |
|
Departments of Internal Medicine and Laboratory Medicine,2 National police Hospital, Seoul, Korea |
|
|
|
|
| Abstract |
|
Background : Strong immunosuppressive regimens have steadily improved both graft and patient survival, but
posttransplant malignancy is still a clinical issue that needs to be resolved.
Methods : There were 1,500 transplant recipients between 1969 and 2005 at Kangnam St. Mary's hospital. The mean
follow-up period was 108 77 months. We retrospectively analyzed the incidence, clinical course, treatment and prognosis
of malignancy in the kidney transplant recipients.
Results : The incidence of malignancy after transplantation was 7.0% (10.5 cases out of 103 patients). The incidence
of malignant lymphoma, thyroid cancer, renal cell carcinoma and Kaposi's sarcoma were higher in the renal transplanted
patients than in the general population. The cancer incidence for women was higher than that for men, with stomach
cancer being the most common in males and uterine cervix cancer the most common in females. The cumulative
incidence of posttransplant malignancy at 1990, 1995, 2000 and 2005 were 0.72%, 2.91%, 4.62% and 7.0%, respectively.
The cancer incidence with the use of initial immunosuppressive agents was 8.3% for azathioprine, 7.6% for cyclosporine,
and 3.4% for tacrolimus. The mean times for making the diagnosis of malignancy after transplantation were 172¡¾61
months for azathioprine, 91¡¾49 months for cyclosporine, and 57¡¾28 months for tacrolimus, respectively. During the
observational period, 37 patients died (21 patients died of cancer) and 51 patients were still alive (7 grafts failed).
Conclusions : The incidence of malignancy after renal transplantation increases according to the longer follow-up
period. An active screening program is needed to lower the incidence of malignancy in renal transplant recipients.(Korean
J Med 73:67-75, 2007)
|
| Key Words:
Kidney transplantation, Malignancy, Incidence |
|
PDF Links
Full text via DOI
Download Citation
