| The impact of uric acid and metabolic syndrome on the incidence of hypertention in a Korean population |
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Ho Jun Chin, Ki Young Na, Yonsu Kim, Dong-Wan Chae, Suhnggwon Kim |
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성균관대학교 의과대학 삼성서울병원 내과학교실, 제주대학교 의과대학 내과학교실2 |
| 원저 : 한국인에서 고요산혈증 및 대사 증후군이 고혈압의 발생에 미치는 영향 |
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진호준, 나기영, 김연수, 채동완, 김성권 |
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Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Internal Medicine, Cheju National University School of Medicine, Cheju, Korea2 |
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| Abstract |
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Backgrouds : Uric acid has been proposed as an important risk factor for the development of primry hypertension.
Many factors related to the serum uric acid level also influence the prevalence and incidence of hypertension. Especially,
hyperuricemia is considered a secondary phenomena of metabolic syndrome. We evaluated the impact of uric acid and
metabolic syndrome on the development of hypertension, with exclusion of the possible effects of confounding factors on
both the uric acid level and the incidence of hypertension.
Methods : We included 2,390 subjects without hypertension who had undergone multiple health check-ups at the
Seoul National University Hospital during the last 10 years. We selected the JNC VII criteria for hypertension and the
modified ATP III criteria for metabolic syndrome.
Results : During the mean follow-up period of 54.3 months, hypertension was developed in 32.2% of the subjects. The
incidence of hypertension in the high uric acid group was higher than that in the low uric acid group. Metabolic
syndrome was an independent risk factor for hypetension and it was closely related to the prevalence of high uric acid
level. Uric acid was also an independent risk factor for hypertension in each gender. The relationship between uric acid
and hypertension was evident for the subjects without metabolic syndrome.
Conclusions : Serum uric acid was a risk factor for hypertension in each gender regardless of the absence of
metabolic syndrome. Metabolic syndorme also contributed to the development of hypertension.(Korean J Med 73:58-66,
2007)
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| Key Words:
Uric acid, Metabolic syndrome, Hypertension |
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