| Prevalence of Helicobacter pylori infection in Korean Patients with Inflammatory Bowel Disease |
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1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea |
| Prevalence of Helicobacter pylori infection in Korean Patients with Inflammatory Bowel Disease |
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| Abstract |
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Background : The incidence of H. pylori infection was reported to be lower in individuals with inflammatory bowel disease
(IBD), especially Crohn's disease, than in the normal populations of some western countries. The aim of this study was to assess
the prevalence of H. pylori infection in Korean patients with IBD and to compare this to a group of normal controls matched
for age and sex. Methods : We studied 97(mean age 40.1 years; women 30) unselected patients with IBD, including 63 with
ulcerative colitis and 34 with Crohn s disease. 270 healthy age- and sex matched subjects(mean age 41.3 years; women 93)
served as controls. Infection rates of H. pylori detected by biopsy or urea breath test were compaired between IBD patients(97)
and the control groups(270). The relationship between drug therapy and the phenotypic characteristics and the prevalence of H.
pylori infection were also analyzed. Results : Concerning positivity for H. pylori infection, significant difference between patients
with IBD(28.9%) and controls(54.1%; P<0.001) was noticed. When analyzed by age, the 15 to 29-year age group(P =0.002) and
the 30 to 44-year age group(P =0.010) had a significantly different positive rate from that in the control group. Among the
previous therapies in patients with ulcerative colitis, steroid(P=0.012) and ciprofloxacin(P =0.027) were significantly related to
lower incidence of H. pylori infecion. The prevalence of H. pylori infection among patients with Crohn s disease was not related
to phenotypic characteristics such as age, location and behavior of disease. Conclusions : Our observations confirm the low
prevalence of H. pylori infection in patients with inflammatory bowel disease. Difference of H. pylori positivity between the
ranges of age may indicate the H. pylori infection influence differently on the bimodal peak age of onset of IBD. No relationship
between treatment with prevalence of H. pylori infection in patients with Crohn s disease has been noticed, but association has
been found between use of steroid and ciprofloxacin in patients with UC, suggesting that prevalence of H. pylori infection may
be inversely correlated with the severity of disease. |
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