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Han Kyu Lee, Young Mo Lee, Joo Kyoung Song, Sa Rah Jeong, Soo Yoon Lee, Dong Seok Jang, Oh Kyung Kwon, Ki Ryang Na, Kang Wook Lee, Young Tai Shin |
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전남대학교 의과대학 내과학교실 |
| 원저 : 투석 전 만성신부전 환자의 신기능에 대한 Erythropoietin의 효과 (Original Articles : Efficacy of erythropoietin in renal function of pre-dialysis patients with chronic renal failure) |
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이한규, 이영모, 송주경, 정사라, 이수윤, 장동석, 권오경, 나기량, 이강욱, 신영태 |
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| Abstract |
Background : Anemia is one of the most important risk factors for cardiovascular morbidity and
mortality in patients with chronic renal failure. The most effective treatment modality for anemia is
erythropoietin injection. Besides erythropoietic effect, erythropoietin has multiple beneficial effects
such as anti-oxidant, anti-hypoxic, anti-apoptotic and vasculogenetic effects, and prevents tubular
lesions and interstitial fibrosis. Despite lots of advantages of erythropoietin therapy, the number of
patients treated with this agent is modest, particularly during the pre-dialysis chronic renal failure.
We conducted a clinical trial to evaluate the effects of erythropoietin on renal function in the anemic
pre-dialysis patients with chronic renal failure.
Methods
: Data of 23 pre-dialysis patients with chronic renal failure were analyzed
retrospectively 6 months prior, and prospectively 6 months after the initiation of erythropoietin
therapy. Erythropoietin was admitted at a dose of 3000 IU weekly with supplementary iron.
Results
: The average hematocrit and hemoglobin rose from 22.1¡¾2.5%, 7.4¡¾0.8 g/dL to 28.4¡¾
4.2%, 9.6¡¾1.5 g/dL, respectively. When linear regression analysis was applied to pre- and
post-erythropoietin glomerular filtration rate and 1/Cr, mean rate of decline of glomerular filtration
rate were significantly delayed (p=0.039) but that of 1/Cr had a tendency to be delayed but was not
statistically meaningful (p=0.099).
Conclusions
: Treatment of the anemia with low dose erythropoietin in pre-dialysis patients with
chronic renal failure is relatively safe and may slow the rate of renal function deterioration.(Korean
J Med 70:138-144, 2006)
Key Words : Erythropoietin, Pre-dialysis patients, Chronic renal failure |
| Key Words:
Erythropoietin, Pre-dialysis patients, Chronic renal failure |
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